Heritable and non-heritable influences explain immune system variation
Human immuns systems are incredible variable, but the sources of this variation remain elusive. Both heritable and non-heritable factors contribute. Recent data suggest that each individual has a unique immune cell composition, that is stable over time in healthy adults in the absence of an infection, vaccination or other stimulating factors (Carr et al, Nature Immunology, 2016, Shen-Orr et al, Cell Systems, 2016, and Tsang et al, Cell, 2014)
Human immune systems vary along a continuum
Healthy individuals vary with respect to their immune cell composition in a manner that changes with age, sex and CMV serostatus.
Functional immune cell responses to stimulation in vitro could be predicted from immune cell composition alone using Partial Least Square regression